Polyoxidovanadates' interactions with proteins: An overview

Polyoxidovanadates (POVs, previously named polyoxovanadates) are a subgroup of polyoxidometalates (POMs, polyoxometalates) with interesting pharmacological actions that have been tested as potential antidiabetic, antibacterial, antiprotozoal, antiviral, and anticancer drugs. They contain mainly vanadium able to interact proteins, affecting various biological processes. The most studied POV is the isopolyoxidovanadate decavanadate (V10), which interacts proteins and/or enzymes such tyrosine protein phosphatases, P-type ATPases, RNA triphosphatases, myosin actin. However, in many POVs–protein systems, binding sites residues involved interaction not identified. In present review, interactions POVs, well linear trivanadate (V3), both cyclic tetravanadate (V4) two proposed heptavanadate (V7; better described by V10 molecules), through X-ray crystallographic studies. Interactions POVs theoretical spectroscopic studies related muscle contraction, serum, oxidative stress, diabetes were also discussed. sum, herein, we describe POVs’ including acid phosphatase A, receptor kinase, ecto-nucleoside triphosphate diphosphohydrolase (NTPDases), transient cation channel (TRPM4), phosphoglucomutases, myosin, actin, transferrin, albumin, glucosidases, among others. putative effects on impacted POV' stability speciation. modes POVs' include H-bond, electrostatic, H-bond + van der Waals, covalent binding. spectroscopic, computational results, detail.